Cortical Hubs

The 'Cortical Hubs' (CHubs) are regions-of-interest defined by cortical thickness differences between older controls and individuals classified as having AD, created using the OASIS data set. These ROIs were used in the study The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease, Sabuncu et al.. See also: Supplemental, and below is a snapshot of a figure from the paper.

Freesurfer v5.2 (and v5.1 local) contains these ROIs as labels, found in the directory $FREESURFER_HOME/subjects/fsaverage/label. There are eight:

FS label name

name used in paper


inferior frontal cortex


inferior parietal cortex


inferior parietal sulcus


lateral temporal cortex


not used in paper


entorhinal cortex (medial temporal lobe)


posterior cingulate


temporalpolar cortex

These labels are also combined into .annot files: ?h.oasis.chubs.annot

To view these on the fsaverage rh surface:

tksurfer fsaverage rh inflated -annotation oasis.chubs

To map these labels to your subject set (which you would define in a SUBJECTS csh shell var), first you will need to symlink the fsaverage subject into your own subjects dir:

ln -s $FREESURFER_HOME/subjects/fsaverage

Confirm that you see 16 .label files and two .annot files:

ls $SUBJECTS_DIR/fsaverage/label/*chubs*

Now you can do the mapping:

foreach s ($SUBJECTS)
    echo $s
    foreach h (lh rh)
        foreach l (\
  .oasis.chubs.ifc \
  .oasis.chubs.ipc \
  .oasis.chubs.ips \
  .oasis.chubs.lateraltemporal \
  .oasis.chubs.mtl \
  .oasis.chubs.retrosplenial \
            set cmd=(mri_label2label \
                --srclabel fsaverage/label/${h}${l} \
                --srcsubject fsaverage \
                --trgsubject $s \
                --trglabel $s/label/${h}${l} \
                --regmethod surface \
                --hemi $h)
            echo $cmd

Snaphot from the Sabuncu paper: chubs.jpg




These are a bunch of scripts (in the /scripts dir) which performed those mappings... see *chubs* files.