Entorhinal Cortex

The entorhinal cortex is located on the crown of the anterior parahippocampal gyrus. Brodmann assigned the number 28 to entorhinal cortex (Brodmann’s area 28). Entorhinal cortex displays a unique cytoarchitecture with large neurons in layer II that form clusters. The entorhinal cortex is the gateway to the hippocampus. In Alzheimer’s disease (AD), neurons in the entorhinal cortex, particularly those in layer II, begin to die and some leave behind a pathological marker – the neurofibrillary tangle. Neurofibrillary tangles and significant cell death characterize the neuronal loss in AD where neurofibrillary tangles and subsequent atrophy have been correlated with dementia.

be sure to discuss the difference between the ec label thats included in the aparc atlas versus this new ec label.

you have three options for using these labels:

labels in freesurfer surface space are in subjects dir subj/label/?h.perirhinal.label

instructions on how to view in freeview

where to get stats on this label (../stats/$hemi.BA.stats)

already in freesurfer 5.3

label in volume space

mapping surface label to subjects volume space

will be available in v6

or if you have freesurfer, run this to map from surface space to volume space and then this is how you view it.

label in fsaverage volume space

perirhinal_fsaverage.nii

label in mni152 volume space

perirhinal_mni152.nii