/* fwdmodel_flex.cc - FLEX model Michael Chappell, IBME PUMMA & FMRIB Image Analysis Group Copyright (C) 2011 University of Oxford */ /* Part of FSL - FMRIB's Software Library http://www.fmrib.ox.ac.uk/fsl fsl@fmrib.ox.ac.uk Developed at FMRIB (Oxford Centre for Functional Magnetic Resonance Imaging of the Brain), Department of Clinical Neurology, Oxford University, Oxford, UK LICENCE FMRIB Software Library, Release 5.0 (c) 2012, The University of Oxford (the "Software") The Software remains the property of the University of Oxford ("the University"). 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Contact details are: innovation@isis.ox.ac.uk quoting reference DE/9564. */ #include "fwdmodel_flex.h" #include #include #include #include "newimage/newimageall.h" #include "miscmaths/miscprob.h" using namespace NEWIMAGE; #include "easylog.h" string FLEXFwdModel::ModelVersion() const { return "$Id: fwdmodel_flex.cc,v 1.1 2011/03/10 13:55:00 chappell Exp $"; } void FLEXFwdModel::HardcodedInitialDists(MVNDist& prior, MVNDist& posterior) const { Tracer_Plus tr("FLEXFwdModel::HardcodedInitialDists"); assert(prior.means.Nrows() == NumParams()); SymmetricMatrix precisions = IdentityMatrix(NumParams()) * 1e-12; // Set priors int place=1; // baseline for (int i=1; i<=npoly; i++) { prior.means(place) = 0.0; precisions(place,place) = 0.01; place++; } // PTR for (int s=1; s<=ncomp; s++) { prior.means(place) = 0.0; place++; } //NB dont really need to worry about these are they will be ARD // deltw (ppm) for (int s=1; s<=ncomp; s++) { prior.means(place) = 0; //compspec(s,1); precisions(place,place) = 1; place++; } // kevol (log) for (int s=1; s<=ncomp; s++) { prior.means(place) = compspec(s,2); precisions(place,place) = 1; place++; } //phase for (int s=1; s<=ncomp; s++) { prior.means(place) = 0; precisions(place,place) = 1; place++; } // Set precsions on priors prior.SetPrecisions(precisions); // Set initial posterior posterior = prior; // For parameters with uniformative prior chosoe more sensible inital posterior posterior.means(1) = 1; precisions(1,1) = 10; place=2; if (npoly>1) { for (int i=1; i<=npoly; i++) { precisions(place,place)=10; place++; } } // for (int s=1; s<=ncomp; s++) { // posterior.means(place) = 0.1; // precisions(place,place) = 10; // place++; // } posterior.SetPrecisions(precisions); } void FLEXFwdModel::Evaluate(const ColumnVector& params, ColumnVector& result) const { Tracer_Plus tr("FLEXFwdModel::Evaluate"); // ensure that values are reasonable // negative check ColumnVector paramcpy = params; for (int i=1;i<=NumParams();i++) { if (params(i)<0) { paramcpy(i) = 0; } } //model matrices ColumnVector baseline(npoly); ColumnVector PTR(ncomp); ColumnVector deltw(ncomp); ColumnVector kevol(ncomp); ColumnVector phase(ncomp); // extract values from params int place=1; baseline = params.Rows(place,place+npoly-1); place += npoly; // PTR PTR = params.Rows(place,place+ncomp-1); place += ncomp; // deltw //deltw = params.Rows(place,place+ncomp-1); ColumnVector pw; pw = params.Rows(place,place+ncomp-1); for (int i=1; i<=ncomp; i++) { if (pw(i)>M_PI/2-1e-12) pw(i) = M_PI/2-1e-12; if (pw(i)<-M_PI/2+1e-12) pw(i) = -M_PI/2+1e-12; deltw(i) = compspec(i,1) + tan(pw(i)); //deltw(i) = compspec(i,1) + pw(i); } place += ncomp; deltw /= 1e6; // starts out in ppm deltw *= field; //into Hz deltw = o1 - deltw; //offset from o1 frequency deltw *= 2*M_PI; //into radians/s // kevol = (ksw-1/T*_2s) kevol = exp( params.Rows(place,place+ncomp-1) ); //infer log(kevol) place += ncomp; //phase phase = params.Rows(place,place+ncomp-1); place += ncomp; result.ReSize(ntpts); result = 0.0; //baseline ColumnVector tpower(tevol); tpower=1; for (int i=1; i<=npoly; i++) { result += baseline(i)*tpower; tpower = SP(tpower,tevol); } for (int s=1; s<=ncomp; s++) { for (int i=1; i<=ntpts; i++) { result.Row(i) += PTR.Row(s)*exp( -kevol.Row(s)*tevol.Row(i) )*cos( (deltw.Row(s)*tevol.Row(i) + phase.Row(s)).AsScalar()); } } return; } FLEXFwdModel::FLEXFwdModel(ArgsType& args) { Tracer_Plus tr("FLEXFwdModel"); string scanParams = args.ReadWithDefault("scan-params","cmdline"); // compspec // 2 Columns: Freq (ppm), kevol (s^-1) // Nrows = number of components if (scanParams == "cmdline") { // read timings from file tevol = read_ascii_matrix(args.Read("tevol")); //in s //read component specificaiton from file compspec = read_ascii_matrix(args.Read("comps")); //read field (Hz) field = convertTo(args.Read("field")); //read FLEX offset o1 = convertTo(args.Read("o1")); npoly = convertTo(args.ReadWithDefault("npoly","1")); } else throw invalid_argument("Only --scan-params=cmdline is accepted at the moment"); ncomp = compspec.Nrows(); ntpts = tevol.Nrows(); //ARD on baseline parameters (except DC term) if (npoly>1) { for (int i=1; i& names) const { names.clear(); // name the parameters for the pools using letters string lettervec [] = {"a","b","c","d","e","f","g","h","i","j","k","l","m","n","o","p","q","r","s","t","u","v","w","x","y","z"}; // baseline for (int i=1; i<=npoly; i++) { names.push_back("BL_" + lettervec[i-1]); } // components for (int i=1; i<=ncomp; i++) { names.push_back("PTR_" + lettervec[i-1]); } for (int i=1; i<=ncomp; i++) { names.push_back("deltw_" + lettervec[i-1]); } for (int i=1; i<=ncomp; i++) { names.push_back("kevol_" + lettervec[i-1]); } for (int i=1; i<=ncomp; i++) { names.push_back("phs_" + lettervec[i-1]); } } void FLEXFwdModel::SetupARD( const MVNDist& theta, MVNDist& thetaPrior, double& Fard) { Tracer_Plus tr("FLEXFwdModel::SetupARD"); if (doard) { //sort out ARD indices Fard = 0; int ardindex; for (unsigned int i=0; i1e12) b=1e12; Fard += -1.5*(log(b) + digamma(0.5)) - 0.5 - gammaln(0.5) - 0.5*log(b); //taking c as 0.5 - which it will be! } } return; }