/* {{{ Copyright etc. */ /* prewhiten - apply prehitening Stephen Smith and Mark Woolrich, FMRIB Image Analysis Group Copyright (C) 1999-2002 University of Oxford */ /* Part of FSL - FMRIB's Software Library http://www.fmrib.ox.ac.uk/fsl fsl@fmrib.ox.ac.uk Developed at FMRIB (Oxford Centre for Functional Magnetic Resonance Imaging of the Brain), Department of Clinical Neurology, Oxford University, Oxford, UK LICENCE FMRIB Software Library, Release 5.0 (c) 2012, The University of Oxford (the "Software") The Software remains the property of the University of Oxford ("the University"). The Software is distributed "AS IS" under this Licence solely for non-commercial use in the hope that it will be useful, but in order that the University as a charitable foundation protects its assets for the benefit of its educational and research purposes, the University makes clear that no condition is made or to be implied, nor is any warranty given or to be implied, as to the accuracy of the Software, or that it will be suitable for any particular purpose or for use under any specific conditions. Furthermore, the University disclaims all responsibility for the use which is made of the Software. It further disclaims any liability for the outcomes arising from using the Software. 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You are not permitted under this Licence to use this Software commercially. Use for which any financial return is received shall be defined as commercial use, and includes (1) integration of all or part of the source code or the Software into a product for sale or license by or on behalf of Licensee to third parties or (2) use of the Software or any derivative of it for research with the final aim of developing software products for sale or license to a third party or (3) use of the Software or any derivative of it for research with the final aim of developing non-software products for sale or license to a third party, or (4) use of the Software to provide any service to an external organisation for which payment is received. If you are interested in using the Software commercially, please contact Isis Innovation Limited ("Isis"), the technology transfer company of the University, to negotiate a licence. Contact details are: innovation@isis.ox.ac.uk quoting reference DE/9564. */ /* }}} */ /* {{{ background theory */ /* consider the GLM: Y = Xb + E consider a single voxel, in which case Y (data) and X (model) and E (residuals) are column vectors (ie time series) we generate a prewhitening matrix S which makes the residuals white: SY = SXb + SE (SPM also uses this form, but in the case of SPM, S is not a whitening matrix but a colouring matrix, so that instead of the resulting residuals being white, they contain an amount of autcorrelation which is approximately known and can be corrected for in the inference.) S is a Toeplitz matrix S = / r0 r1 r2 r3 r4 ....... \ | r-1 r0 r1 r2 r3 ....... | | r-2 r-1 r0 r1 r2 ....... | | r-3 r-2 r-1 r0 r1 ....... | ........................... ........................... ........................... | ....... r-2 r-1 r0 r1 r2 | | ....... r-3 r-2 r-1 r0 r1 | \ ....... r-4 r-3 r-2 r-1 r0 / this is in theory equivalent to convolving the time series in a column vector (Y or X or E) with 1D convolution kernel r[i]; SY[i] = SUM(r[j-i] * Y[j]) the difference in practice is that it is easier to sort out end-effects (padding of the data to allow simple processing with a constant width convolution kernel) if this is seen as a convolution rather than matrix multiplication. In fact, the convolution is normally carried out in fourier space (ie a fourier space multiplication rather than real space convolution) for computational efficiency. *********************************************************** generating prewhitening matrix S: E = N(0,sigma^2 V) where V is the autocorrelation matrix use Cholesky to get K where V=KK' so if we set S = K^-1 there are more details in Mark's report which we've just put on the web: http://www.fmrib.ox.ac.uk/analysis/techrep/tr01mw1/tr01mw1/node3.html in detail: 1) fit model to data and remove that part of signal which correlates. 2) take resulting residuals and estimate autocorrelation parameters 3) regularise these by applying a Tukey taper and the smoothing spatially with the estimates at neighbouring voxels 4) create S=K^-1 by inverting the autocorrelation estimates in the spectral domain 5) Use S to prewhiten data and model, and refit. again - there is more detail in the paper (and the source code ;-) */ /* }}} */ /* {{{ defines, includes and typedefs */ #include "featlib.h" using namespace NEWMAT; using namespace NEWIMAGE; /* }}} */ /* {{{ usage */ void usage(void) { printf("Usage: prewhiten [options]\n"); printf("[-o ] change output directory from default of input feat directory\n"); exit(1); } /* }}} */ int main(int argc, char **argv) { /* {{{ variables */ int argi=1, x, y, z; char fmridata[10000], featdir[10000], outputdir[10000], thestring[10000]; ColumnVector pwts; /* }}} */ /* {{{ process arguments */ if (argc<2) usage(); strcpy(featdir,argv[argi++]); sprintf(fmridata,"%s/filtered_func_data",featdir); strcpy(outputdir,featdir); for (;argi im; read_volume4D(im, fmridata); /* }}} */ /* {{{ read auto correlation estimates for prewhitening */ volume4D acs; sprintf(thestring,"%s/stats/threshac1",featdir); if(fsl_imageexists(thestring)) read_volume4D(acs, thestring); /* }}} */ for(z=0;z